FATXplorer provides the following command line options:
–no-directx: Disables DirectX rendering of certain UI components. DirectX improves performance of the FATXplorer UI. This option was added for one reason: to fix BSODs in certain virtual machine setups. More info in this comment thread. Unless you are getting a BSOD that you think is DirectX related, there is no other reason to disable DirectX rendering using this option.